Anti-inflammatory and Anti-plaque Efficacies of Mouth Rinse Containing Hydrogen Peroxide and Hydrogen Peroxide
Status:
Recruiting
Trial end date:
2023-05-01
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to test efficiency of using mouth rinse containing (H2O2
and HA) over a period of two weeks to control on gingival inflammation and plaque
accumulation through measuring the clinical periodontal parameters (Gingival Index (GI),
Bleeding on probing (BOP) and modified Quigley-Hein Plaque Index (mQHPI ) in comparison with
Chlorhexidine (CHX) and placebo mouth rinses in patients with biofilm induced gingivitis.
Objectives:
- Evaluate the clinical efficiency of using mouth rinse containing (H2O2 and HA) over a
period of 14 days to control on gingival inflammation and plaque accumulation through
measuring the clinical periodontal parameters (Gingival Index, Bleeding on probing and
modified Quigley-Hein Plaque Index in comparison with Chlorhexidine and placebo mouth
rinses in patients with biofilm induced gingivitis.
- Measuring levels of salivary cytokines, Interleukin 1 beta (IL-1B) and Interleukin 6
(IL-6) at baseline visit before using mouth rinse and after 14 days of using the mouth
rinse containing H2O2 and HA compared to chlorhexidine and placebo mouth rinses.
- Investigate and compare the association of salivary concentration of IL-1B and IL-6 in
periodontal health and generalized gingivitis.
- Evaluate the correlation between clinical periodontal parameters and salivary (IL-1B and
IL-6)
- Evaluate subjects' perception of a mouth rinse (H2O2 and HA), CHX and placebo mouth
rinses after 14 days from using three mouth rinse