Anti-inflammatory Treatment at the Onset of Necrotizing Enterocolitis (NEC) in Preterm Infants
Status:
Terminated
Trial end date:
2012-11-01
Target enrollment:
Participant gender:
Summary
Despite modern medical advances, necrotizing enterocolitis (NEC) remains a significant
problem in neonatal intensive care units (ICUs). Although research has shown NEC to be an
inflammatory necrosis of the bowels, to date no study has examined the effect of
anti-inflammatory therapy on this dreaded disease once it is diagnosed. The investigators
propose a multi-center, randomized, placebo-controlled, double-blinded pilot study to examine
the effect of hydrocortisone in infants diagnosed with stages II and III NEC. The
investigators will follow C-reactive protein (CRP) levels as a marker of systemic
inflammation for the primary outcome in this study.
Phase:
N/A
Details
Lead Sponsor:
NorthShore University HealthSystem NorthShore University HealthSystem Research Institute