Anti-inflammatory Effects of Topical Erythromycin and Clindamycin in Acne Patients
Status:
Unknown status
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
The combined bacteriostatic and immunomodulatory effects of erythromycin and clindamycin will
be explored. Treatment effects will be extensively characterized by conventional methods
including lesion counts, global assessment scales and visual grading as well as
state-of-the-art methodology, including multi-modal photo analysis, perfusion by laser
speckle contrast imaging, analysis of local skin surface, biopsy biomarkers and skin
microbiota. This extensive response profiling, combined with the mechanistic insights from
concurrent in vitro and in vivo studies in healthy volunteer challenges, will increase the
understanding of erythromycin's and clindamycin's effects in acne vulgaris.