Anti Tumor Necrosis Factor Alpha Agents and Surgical Stress Response
Status:
Completed
Trial end date:
2016-08-01
Target enrollment:
Participant gender:
Summary
Background: The immunologic response to stress is regulated by the cytokines. Anti-Tumor
Necrosis Factor-α agents are antibodies directed against a key cytokine in the process
angiogenesis and collagen synthesis. It is not known whether they intervene with surgical
stress response increasing the rate of postoperative complications.
Method: Un-blinded prospective, non-interventional cohort single centre study including all
the patients with Crohn's disease and Ulcerative Colitis undergoing abdominal surgery.
Immunological and endocrinological parameters will measured in blood samples taken from these
patients before and after surgery. Power calculations showed that 17 patients in each arm are
needed.