Overview

Anti-Oxidant Effect on Peritoneal Membrane in Peritoneal Dialysis (PD) Patients

Status:
Unknown status
Trial end date:
2011-12-01
Target enrollment:
0
Participant gender:
All
Summary
Peritoneal fibrosis is one of the major causes of technical failure in patients on peritoneal dialysis (PD) for long period of time. Although the exact mechanisms of peritoneal damage during PD still remain unclear, generation of reactive oxygen species may be responsible for progressive membrane dysfunction. N-acetylcysteine (NAC)is a powerful antioxidant shown to protect peritoneal fibrosis in peritoneal dialysis animal model. In this study the researchers investigated the hypothesis that NAC protect peritoneal membrane damage.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Ewha Womans University
Treatments:
Acetylcysteine
N-monoacetylcystine
Criteria
Inclusion Criteria:

- Maintenance peritoneal dialysis at least 3 months

- Patients who are able and willing to understand, sign and date an informed consent
document, and authorize access to protected health information

Exclusion Criteria:

- Episode of peritonitis at least 3 months

- Episodes of admission due to other disease at lease 3 months

- Liver disease

- Allergic history with N-acetylcysteine