Overview

Anti-Nephropathic Effects of Chronic Intermittent Intravenous Insulin Therapy (CIIIT)

Status:
Completed

Trial end date:
1995-01-01

Target enrollment:
0

Participant gender:
All

Summary

Investigators with the goal of optimizing glycemic and blood pressure control saw type 1 diabetic patients weekly. A control group received 3-4 subcutaneous insulin injections per day; an intravenous insulin pulsed infusion group received, in addition, three one hour infusions in a pulsatile fashion over one eight hour period each week. Patients were followed for 12 months with periodic testing of renal function by repeated blood and urinary analyses; diabetes control by blood testing and diabetes impact measurement score; cardiac and autonomic function by echocardiography, 24 hour electrocardiographic testing; and visual changes with repeated fundus photography. The study hypothesis was that correction of respiratory quotient would correct the defect leading to microvascular complications of diabetes (Type 1).

Phase:

Phase 3

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Joslin Diabetes Center

Treatments:

Insulin
Insulin, Globin Zinc

Criteria

Inclusion Criteria:

- Type 1 diabetics with proteinuria willing to be seen weekly for the evaluation of
renal function

Exclusion Criteria:

- Associated active medical diseases that would not permit evaluation of stable renal
disease over 18 months