Anthocyanin-Rich Table Grape Powder for Prophylaxis of Post-Operative Atrial Fibrillation
Status:
Not yet recruiting
Trial end date:
2025-06-01
Target enrollment:
Participant gender:
Summary
Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery
and leads to worse outcomes. POAF is thought to be caused by the inflammatory state following
cardiac surgery. It may be that anti-inflammatory medications could lower the occurrence of
POAF, however many typical anti-inflammatory medications, such as ibuprofen, are
contraindicated in the post cardiac surgery patient due to increased risks of bleeding. If a
drug was identified with anti-inflammatory properties with minimal deleterious side effects,
this could be broadly applied to cardiac surgery patients for the prevention of POAF.
Interestingly, several small trials have shown that medications that alter transcription of
inflammatory markers lead to decreased POAF. Furthermore, we have shown that phytochemicals,
such as those found in grapes, have excellent bioavailability and can affect cardiac gene
transcription related to inflammation. In this study, we propose to evaluate the efficacy of
preoperative administration of concentrated grape powder in the prevention of POAF.