Anterior Pituitary Hormone Replacement in Traumatic Brain Injury
Status:
Completed
Trial end date:
2015-10-01
Target enrollment:
Participant gender:
Summary
Fifteen to twenty percent of adults who suffer a traumatic brain injury (TBI) that requires
hospitalization and rehabilitation have been found to have growth hormone (GH) deficiency by
GH stimulation testing. Moreover, abnormalities have also been established for the cortisol
and thyroid axis. The hypothesis of this proposal is that hormone replacement in TBI patients
with documented abnormalities in the GH, thyroid, or cortisol axis will improve muscle
function, body composition, aerobic capacity (GH) and tests of neuropsychologic function (GH,
thyroid, cortisol).