Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage
Status:
Completed
Trial end date:
1997-02-01
Target enrollment:
Participant gender:
Summary
This large randomized trial tested whether phenobarbital given to a pregnant woman about to
deliver a premature infant would prevent brain injuries in their newborns. Women with 24 to
32 week fetuses who were in preterm labor and were expected to deliver within 24 hrs were
randomized to phenobarbital or usual care. They were treated until they deliver or the fetus
reaches 33 wks gestation. Babies were followed until discharge and evaluated at 18-22 mos
corrected age for neurodevelopmental outcome.