Overview

Anlotinib In Combination With Durvalumab As Sequential Therapy of Thoracic Radiotherapy After Induction Chemotherapy For Extensive-Stage Small Cell Lung Cancer:A Single Arm Study

Status:
Not yet recruiting
Trial end date:
2022-02-01
Target enrollment:
0
Participant gender:
All
Summary
Anlotinib In Combination With Durvalumab As Sequential Therapy of Thoracic Radiotherapy After Induction Chemotherapy For Extensive-Stage Small Cell Lung Cancer:A Single Arm Study
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Wuhan Union Hospital, China
Treatments:
Antibodies, Monoclonal
Durvalumab
Criteria
Inclusion Criteria:

- The subjects volunteered to join the study and signed the informed consent form. They had
good compliance and cooperated with the follow-up; Patients between 18-75 years old;
Extensive small cell lung cancer confirmed by histopathology (according to Veterans
Administration lung study group, Valg stage) and did not progress after 4-6 cycles (21 days
as a cycle) of first-line standard chemotherapy platinum combined with etoposide [complete
remission (CR), partial remission (PR) or stable (SD) according to recist1.1 standard]; The
time interval between the first TRT and the end of the last chemotherapy should be less
than or equal to 6 weeks; The life expectancy shall be at least 3 months; ECoG score: 0-1

Exclusion Criteria:

- Small cell lung cancer patients with other pathological types of tumor species; Patients
with pathological fracture in bone metastasis of small cell lung cancer; Patients with
central nervous system metastasis; Patients who have received chest radiotherapy before;
Patients who have used vasotargeted drugs (such as bevacizumab, sunitinib, etc.) including
enrotinib and immunosuppressive agents before; Imaging (CT or MRI) showed that the distance
between the tumor focus and the large blood vessel was less than or equal to 5 mm, or there
was a central tumor invading the local large blood vessel, or there was an obvious cavitary
or necrotic tumor in the lung;