Anidulafungin Versus Fluconazole for the Prevention of Fungal Infections in Liver Transplant Recipients

• Status: Completed
• Trial end date: 2014-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the efficacy of anidulafungin versus fluconazole for the prevention of fungal diseases in liver transplant recipients

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Pittsburgh
• Treatments: Anidulafungin; Antifungal Agents; Echinocandins; Fluconazole

Criteria

Inclusion Criteria:

• Liver transplant recipient at increased risk for infection increased risk include any of the following:

• retransplantation

• renal replacement therapy (dialysis),

• post transplant abdominal surgery (within 21days)

• receipt of corticosteroids for greater than 14 days within the 4 weeks -preceding transplant

• ICU care for greater than 48 hours at the time of transplantation

• colonization with Candida sps within 4 weeks of transplantation

• requirement of 15 units or greater of packed red cell transfusions

• Intraoperative time exceeding 6 hours

Exclusion Criteria:

• Hypersensitivity to azole or echinocandin antifungal agents

• receipt of systemic antifungal therapy within 4 weeks prior to transplantation