Anhedonia, Development, and Emotions: Phenotyping and Therapeutics
Status:
Recruiting
Trial end date:
2025-10-01
Target enrollment:
Participant gender:
Summary
The goal of the ADEPT Study is to understand anhedonia in young people and how it changes
based on treatments targeting the brain circuit underlying it. Anhedonia is a challenging
mental health symptom that involves difficulty with motivation to experience pleasant events.
This study could help develop treatments for people whose depression does not improve with
traditional treatments.
The ADEPT Study includes two phases. In Phase 1, participants are asked to go through a
series of activities to measure anhedonia, including MRI scans, blood draws, behavioral
tasks, clinical interviews, questionnaires, and app-based assessments of experiences and
behaviors. Phase 2 involves therapeutic activities, such as transcranial magnetic stimulation
(TMS), positive affect training, and, for some people, ketamine administration. If the
participant qualifies and is interested, they may choose to do Phase 2 activities in addition
to Phase 1.