Angiotensin Receptors and Age Related Mitochondrial Decline in HIV Patients
Status:
Terminated
Trial end date:
2016-08-04
Target enrollment:
Participant gender:
Summary
This study is designed to evaluate specific factors in mitochondria that may precipitate
premature aging and physical weakness in HIV patients. Angiotensin receptors 1 and 2 (AT1R
and AT2R) are found in virtually every cell type. This study will evaluate how the
relationships among these receptors in immune and skeletal muscle cells change with HIV, and
how these changes might trigger mitochondrial dysfunction, declines in muscle strength, and
cellular decline in people living with HIV.