Anesthetic Efficacy of Liposomal Prilocaine in Maxillary Infiltration Anesthesia

• Status: Completed
• Trial end date: 2009-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This blinded randomized, crossover, three period study aim to evaluate the anesthetic efficacy of liposome-encapsulated 3% prilocaine compared to 3% plain prilocaine and 3% prilocaine with 0,03IU/mL felypressin, after 1.8mL infiltration in the buccal sulcus of the maxillary right canine, in 32 volunteers.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Campinas, Brazil
• Collaborators: Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo
• Treatments: Anesthetics; Prilocaine

Criteria

Inclusion Criteria:

• good health

• no history of allergy to the components of the local anesthetic formulations tested

• maxillary canine, lateral incisor, and first premolar responsible to electric stimulation

Exclusion Criteria:

• intake of any medication that would alter pain perception

• history of trauma or sensitivity, caries, restorations, periodontal disease and endodontic treatment in the maxillary canine, lateral incisor, and first premolar

• systemic disease