Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery

• Status: Unknown status
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

• It has been shown that patients who undergo liver resection surgery are at high risk for postoperative acute kidney injury (AKI).

• Sevoflurane may increase the risk for postoperative AKI because of production of compound-A.

• Therefore, we have planned to investigate the effects of different anesthetic agents on postoperative renal function.

• Patients undergoing liver resection surgery are randomized into 2 groups.

• One of the groups receives sevoflurane and the other group receives desflurane.

• Blood and urine specimen are sampled both pre- and postoperatively, and several biomarkers are compared between the groups.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tokyo Medical and Dental University
• Treatments: Anesthetics; Desflurane; Isoflurane; Sevoflurane

Criteria

Inclusion Criteria:

• Forty adult patients (20 patients in each group) who are planned to undergo liver resection surgery are included.

Exclusion Criteria:

• Patients who undergo less invasive resection surgery under thoracoscopy or laparoscopy are excluded. Patients with chronic kidney disease, or allergic to any anesthetic agents used in the study are also excluded.