Anesthesia and Lymphocytes Apoptosis

• Status: Completed
• Trial end date: 2014-10-01
• Target enrollment: 0
• Participant gender: Male

Summary

Most researches revealed that volatile anesthetic sevoflurane has a more marked cardioprotective effect against ischemia compared with intravenous agent propofol.However, propofol has been suggested to be more benefit for attenuation of surgery-induced immunosuppression.Thus, the aim of this study was to investigate under the specific OPCAB surgical stress, the influence of 3 established anesthetic techniques: sevoflurane, propofol and combine of sevoflurane and propofol maintained anesthesia on the apoptosis of circulating lymphocytes.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ruijin Hospital
• Treatments: Anesthetics; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• male adults

• aged 18-80 yr

• undergoing elective OPCAB surgery containing left anterior descending artery bypass

Exclusion Criteria:

• a previous unusual response to any of the experimental anesthetics

• severe cardiac dysrhythmias or ejection fraction below 30%

• hemodynamic instability

• previous surgical coronary artery repair

• anemia, abnormal leukocytes or coagulopathy

• severe hypertension

• severe hepatic (albumin<30g,ascites), renal (serum creatinine greater than 2.0 mg/dl) or pulmonary (preoperative pulmonary function tests moderate-severe) dysfunctions

• concomitant surgical procedures and psychiatric disorders

• Insulin-dependent diabetics