Androgen Blockade and Progesterone Augmentation of Gonadotropin Secretion
Status:
Recruiting
Trial end date:
2025-10-01
Target enrollment:
Participant gender:
Summary
This study is trying to find out if flutamide (a medication that blocks the effects of
testosterone) may help normalize an aspect of pituitary function (specifically, gonadotropin
surge generation) in PCOS. This is a randomized, placebo-controlled, double-blinded,
crossover study. The investigators hypothesize that in estradiol-pretreated women with PCOS,
acute progesterone augmentation of FSH release (positive feedback) will be enhanced by
flutamide.
Phase:
Early Phase 1
Details
Lead Sponsor:
University of Virginia
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)