Overview
Analysis of the Impact of Helicobacter Pylori on Salivary Microbiome in Adults
Status:
Unknown status
Unknown status
Trial end date:
2018-11-20
2018-11-20
Target enrollment:
0
0
Participant gender:
All
All
Summary
Helicobacter pylori (H. pylori), a bacteria transmitted from human to human through upper digestive tract as well as fecal-oral transmission, had infected more than half of people around the world. However, the quantity of H. pylori in oral cavity and its influence on oral microbiota remains to be unclear. The aim of the present study was to examine the effects of H. pylori infection as well as its eradication on oral microbiota.Phase:
Phase 4Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Shanghai Jiao Tong University School of MedicineTreatments:
Amoxicillin
Bismuth
Citric Acid
Esomeprazole
Metronidazole
Potassium Citrate
Criteria
Inclusion Criteria:- Participants with non-ulcer functional dyspepsia or peptic ulcer disease
- Ability and willingness to participate in the study and to sign and give informed
consent
- Received both endoscopy and 13C urea breath test (13C-UBT) before enrolled
Exclusion Criteria:
- Less than 18 years old
- With previous gastric surgery
- Major systemic diseases
- Pregnancy or lactation
- Allergy to any of the study drugs Administration of antibiotics, bismuth,
antisecretory drugs in 8 weeks prior to inclusion
- The use of antibiotics or PPI within 2 months before the study
- The presence of dental carious or any untreated cavitated carious lesions and oral
abscesses