Aim: The aim of the study was to to compare the analgesic effects of ketamine over fentanyl
combined with propofol in analgesia-based elective colonoscopy with purpose of patient safety
and satisfaction.
Methods: This is a double-blinded prospective randomized controlled trial. Ninety patients
were included and randomized to either fentanyl-propofol (Group FP, n: 30), ketamine-propofol
(Group KP, n: 30) or propofol-control group (Group C, n: 30). Group FP patients received
fentanyl and propofol, Group KP received ketamine and propofol and Group C, propofol. In all
groups, incremental doses of propofol were used to maintain a Ramsay sedation score (RSS) of
5. Respiratory depression, hemodynamic parameters were monitored for the first minute and
every 5 minutes during endoscopy. Fifteen minutes after the procedure, the degree of pain was
assessed using a visual analog scale (VAS), the quality of recovery according to the Aldrete
score (ARS), complications during and after the procedure and additional doses of propofol
were recorded.