Analgetic Effect of Preoperative Pregabalin in Patients Undergoing Nephrectomy

• Status: Completed
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Pregabalin 300mg or placebo are administered 1 hour preoperatively in patients undergoing elective nephrectomy. Postoperatively, patients receive a patient controlled analgesia device for self delivering opioids. Morphine consumption in the first 48 hours is documented.

Hyperalgesia is measured by von-Frey-Filaments.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Medical University of Graz
• Treatments: Pregabalin

Criteria

Inclusion Criteria:

• patients undergoing elective nephrectomy

Exclusion Criteria:

• contraindication against pregabalin

• creatinine > 2.0 mg/dl

• GGT >165, AST >105, ALT >135

• peptic Ulcus

• haemorrhagic diathesis

• angina pectoris, myocardial infarction

• stroke

• bronchial asthma

• opioid abuse