Analgesic and Antioxidant Effects of Melatonin in Pediatric Surgery
Status:
COMPLETED
Trial end date:
2024-09-01
Target enrollment:
Participant gender:
Summary
Background. Long-term consequences of postoperative pain are detrimental in children. We tested the hypothesis that melatonin reduces postoperative pain and oxidative stress involving sirtuin pathway in children undergoing surgery.
Methods. Thirty-one children were randomly assigned to oral supplementation with melatonin or placebo, before surgery. Plasma levels of 4-hydroxynonenal (4-HNE), melatonin, sirtuin 1 (SIRT1), and circulating miR-34 and miR-124a were analyzed at T0 (pre-hospitalization), T1 (before surgery), and T2 (1 h after the end of the surgery).
Phase:
NA
Details
Lead Sponsor:
University of Parma
Collaborators:
University of Florida University of Messina University of Siena University of Urbino "Carlo Bo"