Analgesic and Antihyperalgesic Effects of Morphine and Buprenorphine
Status:
Completed
Trial end date:
2011-10-01
Target enrollment:
Participant gender:
Summary
Tissue injury is associated with pain from the injured site (primary hyperalgesia) and pain
from non-injured tissue in the vicinity of the trauma (secondary hyperalgesia). In the
present study we investigate primary and secondary hyperalgesia in healthy volunteers
following an experimental first degree burn injury.
The objectives are:
- to compare analgesic and anti-hyperalgesic effects of two opioids (morphine and
buprenorphine).
- to investigate if these effects are related to the volunteers individual pain
sensitivity