Analgesic Efficacy of (MSIR)/Acetaminophen vs. Oxycodone/Acetaminophen (Percocet)
Status:
Completed
Trial end date:
2020-12-22
Target enrollment:
Participant gender:
Summary
Oxycodone and Hydrocodone are the most commonly used oral opioid analgesics in the emergency
department and in outpatient settings. Both medications have a very high potential for abuse
due to the prominence of the euphoric effect (abuse liability) and relative lack of "bad "or
"negative" effects (likeability). The highly addictive properties of these medications lead
to recurrent ED visits for repetitive dosing and prescribing that may lead to abuse, misuse,
development of dependence and addiction, and, most importantly, death due to overdose. In
contrast, several research papers demonstrated that administration of MSIR results in similar
analgesic efficacy to Oxycodone and Hydrocodone but with significantly less euphoric and
rewarding associated effects. In addition, consumption of large doses of MSIR leads to
dysphoria, vomiting and sedation ("negative effects"). To the investigators' knowledge, there
are no randomized controlled trials in the ED that directly compared analgesic efficacy of
MSIR to Percocet
Phase:
Phase 2
Details
Lead Sponsor:
Antonios Likourezos
Treatments:
Acetaminophen Acetaminophen, hydrocodone drug combination Analgesics Morphine Oxycodone