This research is about the effects of drug gabapentin; which is an amino acid that is
structurally similar to neurotransmitter GABA. It is a novel drug used for the treatment of
postoperative pain with analgesic properties having unique mechanism of action. This study
reviews clinical effects of this agent in hand injury patients managed at the Department of
Plastics & Reconstructive Surgery, Dow University of Health Sciences & Dr. Ruth KM Pfau Civil
Hospital Karachi.
This study aims to inquire the analgesic properties of gabapentin in the patients and to
further investigate its comparison with the equivalent dose of paracetamol given 6 hours
after undergoing operative procedure. Acetaminophen is well tolerated when administered in
therapeutic dose for pain management. It is a principal drug used as pain reliever and as an
antipyretic regimen.
This is an experimental study in which a pre-coded questionnaire would be approved in the
research for appraising the intensity of pain after intervening operative procedure using
visual analogue scale, measuring the pain intensity from 0-10. The questions regarding pain
intensity will be inquired after administrating the drug six hours postoperatively. The drug
will be prescribed by the doctor on duty having no knowledge regarding the given drug or the
group in which he/she is administrating the drug; further questionnaire will be filled by the
two co-investigators who will be trained by principal investigator, how to take correct
information.
Sample size was calculated using www.openepi.com using the previous literature searches of
similar research and 50 patients (25 in each group) will be randomly selected from the ward
of a known case of hand injury. Group A patients will receive 600 mg of gabapentin post
operatively while group B will receive 1 g of paracetamol for management of pain
postoperatively orally.