Analgesic Effect of Intrathecal Morphine Combined With Low Dose Local Anesthetics on Postoperative Analgesia After Liver Resection

• Status: Completed
• Trial end date: 2020-04-18
• Target enrollment: 0
• Participant gender: Male

Summary

Efficient postoperative pain control plays a vital part in the management of patients after surgery. In particular, major surgeries including hepatectomy cause intense postoperative pain that may result in cardiovascular or respiratory complications post-surgery. One of the current methods of postoperative pain control after hepatectomy involves a multimodal approach including intrathecal morphine injection immediately prior to surgery. Because morphine alone is inadequate for immediate postoperative pain control due to a late peak effect time of 6 hours, current literature advocates a combination injection including bupivacaine. However, higher doses of bupivacaine may inadvertently cause motor block or hemodynamic side effects. The aim of this study was to compare the effectiveness and side effects of intrathecal morphine combined with low dose bupivacaine against intrathecal morphine alone and no intrathecal injection.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Yonsei University
• Treatments: Bupivacaine; Morphine

Criteria

Inclusion Criteria:

1. Age 19 years to no upper limit

2. Patients receiving liver resection under general anesthesia (Including open surgery and laparoscopic surgery)

3. American Society of Anesthesiologists (ASA) physical status 1,2

Exclusion Criteria:

1. Patients presenting with coagulopathy prior to surgery

2. Patients with neurological deficits

3. Patients with spinal anomaly or disorders

4. Patients with allergies to opioids or local anesthetics

5. Patients with severe respiratory, cardiovascular, renal, or hepatic disorders

6. Severe systemic infection or infections involving proposed intrathecal injection site

7. Patients with severe psychological disorders severe that may interfere with pain evaluation

8. Patients with chronic diseases that require opioids