Analgesic Effect of Intraoperative Intravenous S-Ketamine After Total Knee Arthroplasty Surgery
Status:
Recruiting
Trial end date:
2024-03-01
Target enrollment:
Participant gender:
Summary
Severe acute pain after total knee arthroplasty surgery has multiple implications for
hospitals and patients, monopolising resources and affecting the quality of life. S-ketamine
inhibits N-methyl-d-aspartate (NMDA) receptor activation and attenuates central sensitization
associated with hyperalgesia, opioid tolerance.Therefore, the primary aim of this trial was
to investigate whether s-ketamine decreases pain and opioid consumption postoperatively in
adult individuals undergoing total knee arthroplasty surgery.