Analgesic Effect of Gabapentin in Total Knee Arthroplasty (TKA)

• Status: Completed
• Trial end date: 2013-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Pain is a major problem after TKA. Gabapentin may reduce acute postoperative pain. The investigators therefore investigate the effect of Gabapentin as a perioperative analgesic.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hvidovre University Hospital
• Collaborator: Lundbeck Foundation
• Treatments: Analgesics; Gabapentin; gamma-Aminobutyric Acid

Criteria

Inclusion Criteria:

• Primary, unilateral total knee arthroplasty (TKA)

• Age 50-85 years

• Ethnic Danes

Exclusion Criteria:

• Treatment with gabapentins, systemic glucocorticoids, opioids, anxiolytic agents, antiepileptics or antidepressive agents (last 4 weeks)

• History of depression or mania

• History of alcohol or drug abuse

• History of malignancy

• History of epilepsia

• BMI > 40

• Disease affecting central or peripheral nerve function

• History of dementia

• History of renal insufficiency

• Allergy to Gabapentin

• Women with menstruation (last 2 years)