Overview
AnalgeSiC and appEtite-stimulating Effects of caNnabigerol and THC (ASCENT)
Status:
Not yet recruiting
Not yet recruiting
Trial end date:
2025-04-01
2025-04-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
This study will assess the analgesic, appetite-stimulating, and subjective effects of cannabigerol (CBG) alone and in combination with THC.Phase:
Phase 1Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
University of California, Los AngelesCollaborator:
Center for Medicinal Cannabis ResearchTreatments:
Dronabinol
Criteria
Inclusion Criteria:- Male or non-pregnant and non-lactating females aged 21-55 years
- Report monthly use of cannabis (≤1 day per week) over the 6 months prior to screening,
- Not currently seeking treatment for their cannabis use
- Have a Body Mass Index from 18.5 - 34kg/m2.
- Able to perform all study procedures
- Must be using a contraceptive (hormonal or barrier methods)
Exclusion Criteria:
- Meeting DSM-V criteria for moderate-severe Cannabis Use disorder (CUD) or any
substance use disorder other than nicotine, caffeine, or mild CUD
- Any other Axis I disorder
- Report using other illicit drugs in the prior 4 weeks
- Current use of prescription analgesics, or any medications that may affect study
outcomes
- If medical history, physical and psychiatric examination, or laboratory tests
performed during the screening process are not within the normal range and / or reveal
any significant illness (e.g., hypertension) as judged by the study physician and to
put the participant at greater risk of experiencing adverse events due to completion
of study procedures.
- Current pain
- Pregnancy is exclusionary due to the possible effects of the study medication on fetal
development.
- History of an allergic reaction or adverse reaction to cannabis is exclusionary.
- History of respiratory illness or current respiratory illness
- Currently enrolled in another research protocol
- Not using a contraceptive method (hormonal or barrier methods)
- Insensitivity to the cold water stimulus of the Cold Pressor Test
- Any disorders that might make cannabis administration hazardous are exclusionary, as
determined by the evaluating physician