Anakinra vs Prednisone to Treat Gout Flare in Patients With Chronic Kidney Disease Stage 4/5 or Renal Transplantation

• Status: Not yet recruiting
• Trial end date: 2024-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Gout is secondary to urate crystal deposition after chronic elevation of serum urate level. Urate crystal deposition is responsible for acute and recurrent inflammatory flares which can be treated with colchicine, non-steroid anti-inflammatory drugs (NSAID), corticosteroid or interleukin (IL)-1b blockade. Colchicine and NSAID are contra-indicated in patients with chronic renal disease (CKD) stage 4/5 or with renal transplantation. In these patients gout flare is treated with high dose of corticosteroid or IL-1b inhibitors.

Frequent use of high dose of corticosteroid can worsen gout comorbidities including mellitus diabetes type 2, hypertension, obesity and dyslipidemia. Anakinra, an IL-1b receptor antagonist, is efficient in gout flare in patients without CKD stage 4/5.

The aim of this study is to demonstrate that anakinra is superior to prednisone to treat gout flare in patients with CKD 4/5 or renal transplantation.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Interleukin 1 Receptor Antagonist Protein; Prednisone

Criteria

Inclusion Criteria:

• Adults aged over 18 years old

• Gout confirmed by identification of urate crystals by joint fluid or tophus analysis or by ultrasound of the affected joint or

• Gout according to Nijmegen criteria (presence of a score ≥ 8/13) depending on the following items:

Man (2 pts) Previous crisis (2 pts) Involvement of first metatarsophalangeal joint (MTP1) (2.5 pts) Maximum pain within 24 hours (0.5pt) Redness (1 pt) HTA or cardiovascular disease (1.5 pts) SUL > 360 μmol/l during the crisis (3.5 pts)

• Chronic kidney disease stage 4/5 or renal transplantation

• Flare ≤ 5 days

• Pain assessed by visual analogical scale ≥ 5

Exclusion Criteria:

• Participating in another trial including the administration of a drug

• Active infection

• History of anakinra or prednisone allergy

• Contra-indication of anakinra or prednisone

• Neutrophil count < 1000/mm3 (not due to ethnic cause)

• Difficulty understanding French

• Illiteracy

• Pregnant women or breastfeeding mothers (see PHC article L.1121-5)

• Persons deprived of liberty by judicial or administrative decision, persons receiving psychiatric care under Sections L. 3212-1 and L. 3213-1 and persons admitted to a health or social institution for purposes other than research (see CSP Article L.1121-6)

• Major persons subject to a measure of legal protection or unseeding to express consent (see PHC Article L.1121-8)

• Persons not affiliated to a social security plan or beneficiaries of such a plan (see PHC Article L.1121-8-1)