Background:
- Behcet's disease (BD) is an autoimmune disease where the immune system attacks the body.
People with BD may develop oral or genital ulcers, skin problems, and eye disease. Most drugs
used to treat BD suppress the immune system, but they are not always helpful and may have
side effects. A new drug, anakinra, may be able to treat BD with fewer side effects. Because
it has not been studied in people with BD, anakinra is considered an experimental treatment.
Objectives:
- To test whether anakinra can be a safe and effective treatment for Behcet s disease.
Eligibility:
- People who have Behcet's disease with ongoing oral or genital ulcers for at least one
month, or three or more flares of eye disease in the past 6 months.
Design:
- Participants will be screened with a physical exam and medical history. They will also
have blood and urine tests. They will be divided into two groups: those with oral or
genital ulcers and those with eye disease.
- All participants will keep a diary of symptoms for a month before starting the study
drug.
- Participants with oral or genital ulcers will receive daily injections of anakinra for 3
to 6 months. Treatment will be monitored with frequent blood draws and daily diaries.
Those who improve but do not have a full response to the drug may receive a higher dose.
Those who improve after 6 months may have an extra 6 months on either anakinra or
placebo to study the differences in response.
- Participants with eye disease will receive anakinra for up to 12 months. Treatment will
be monitored with frequent blood draws, daily diaries, and regular eye exams.
- All participants will have a final study visit 1 month after stopping the study drug.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)