Anakinra as a Rescue Treatment for Allergic Inflammation
Status:
Suspended
Trial end date:
2023-10-01
Target enrollment:
Participant gender:
Summary
Participants with mild asthma who are sensitized to either house dust mite or cat hair
allergen will undergo nasal instillation of the allergen to elicit nasal allergy symptoms.
The participants will be treated in a cross-over fashion with either placebo (saline) or
anakinra to determine if anakinra will reduce nasal airway eosinophil recruitment, eosinophil
activation, release of inflammatory mediators, mucins, and gene expression changes in
epithelial cells.