Anabolic and Inflammatory Responses to Short-Term Testosterone Administration in Older Men
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
Skeletal muscle loss is a common consequence of aging and in some individuals reaches a level
that compromises health and quality of life. Age-associated increases in cytokine and
inflammatory signaling may be important contributors to this process.
The investigators will assess the practical question of whether testosterone injection and
gel application elicit similar responses. Resistance exercise will be used as a means of
stimulating both inflammatory and anabolic responses in skeletal muscle. In order to assess
the effects of testosterone on these responses, subjects will perform resistance exercise on
two occasions separated by 7 days. The first session will be performed prior to the
initiation of testosterone and/or medrol therapy and the second session will be performed
after receiving therapy for 7 days.