An in Situ Study on the Impact of Fluoride Dose and Concentration in Milk on Its Anti-caries Efficacy
Status:
Completed
Trial end date:
2013-06-01
Target enrollment:
Participant gender:
Summary
The study will be randomized, investigator-blind, observer-blind, laboratory analyst-blind
and will utilize a 5-way cross-over study design with a primary objective to determine if a
higher dose of fluoride in milk will provide a greater caries preventive effect. Secondary
objectives are to determine in a higher concentration of fluoride in milk will provide a
greater caries preventive effect and if the caries preventive effect of fluoridated milk
follows a dose-response pattern.