An Open Label Trial of Azithromycin in Chronic Productive Cough
Status:
Unknown status
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
We have noticed a group of patients presenting with a longstanding wet cough which has often
been treated as asthma. The cough is productive of sputum which frequently contains bacteria,
but does not resolve with standard antibiotic treatment.
A very similar cough is seen in subjects who smoke, have exposure to airbourne dusts or
chemicals or have a condition known as bronchiectasis, but these problems have already been
excluded.
We have found that prolonged treatment with an antibiotic called azithromycin is very
effective but using azithromycin in this way is not licensed and there is currently no trial
evidence to support its use.
This research will evaluate the clinical benefit of low dose azithromycin to determine if
this is an effective and safe treatment for these patients. It will also involve a detailed
investigation of these patients to determine whether they have enough in common to believe we
are describing a new condition.