An Open Label Study to Examine the Effect of Coated Nifedipine Suppositories on Anal Pressure in Healthy Subjects
Status:
Completed
Trial end date:
2009-04-01
Target enrollment:
Participant gender:
Summary
This is an open label, dose-finding study. Approximately 8 healthy subjects will be
participating in this study.
Within one week after the screening visit, subjects who meet all inclusion criteria and none
of the exclusion criteria will enter a one day treatment period. During this period, 4 anal
manometric studies will take place. Study medication (Coated Nifedipine suppositories at
various doses) will be administered at pre-determined intervals. During the study, blood
samples will be obtained for plasma Nifedipine analysis.