An Open-Label, Staggered Rising Dose Cohort Study Assessing the Pharmacokinetics, Safety, and Tolerance of BI-RG-587 in Combination With Zidovudine in Patients With HIV Infection (CD4+ Cell Count < 400/mm3)

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

To assess the safety and tolerance of multiple oral doses of nevirapine in combination with zidovudine (AZT); to get information on the pharmacokinetics (blood levels) and dose proportionality of nevirapine/AZT with multiple dosing; to characterize the pattern of virological activity in vivo (in humans) of nevirapine in combination with AZT; to determine whether development of resistance to either drug is slowed by the use of the combination.

Drugs now used in treatment for patients with AIDS show some toxicity which limits their usefulness. In addition, with long-term treatment with AZT, there is evidence of virus resistance to the drug. Compounds that are more effective and less toxic than those in present use would be beneficial, especially if they are active against AZT-resistant viruses. Nevirapine has shown in vitro (test tube studies) activity in inhibiting HIV replication (reproduction). In vitro studies have shown that nevirapine and AZT work together to inhibit HIV replication.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Boehringer Ingelheim
• Treatments: Nevirapine; Zidovudine

Criteria

Inclusion Criteria

Concurrent Medication: Included:

Pneumocystis carinii pneumonia prophylaxis (other than sulfamethoxazole alone or in combination with other medications).

• Antifungal prophylaxis with oral fluconazole or ketoconazole.

• Antiviral prophylaxis with a maximum of 1 g/day oral acyclovir.

Patients must have the following:

• HIV infection.

• Ability to voluntarily provide written informed consent prior to treatment.

• Willing and able to follow protocol requirements.

• Patients with nonvisceral Kaposi's sarcoma or with visceral Kaposi's sarcoma not requiring chemotherapy and/or irradiation may be included.

Exclusion Criteria

Co-existing Condition:

Patients with the following conditions or symptoms are excluded:

• Radiographic evidence of chronic pulmonary disease.

• Cytomegalovirus disease.

• Toxoplasmosis encephalitis requiring suppressive therapy.

• Mycobacteriosis requiring maintenance chemotherapy.

• Visceral Kaposi's sarcoma requiring chemotherapy and/or irradiation.

Concurrent Medication:

Excluded:

• Glucocorticoids and steroid hormones (including oral contraceptives).

• Dicumarol, warfarin, and other anticoagulant medications.

• Nitroglycerin.

• Digitoxin.

• Valproic acid.

• Tolbutamide.

• Doxycycline.

• Chloramphenicol.

• Isoniazid.

• Antiepileptics (Phenobarbital and other barbiturates).

• Sulfonamides.

Excluded for up to 4 hours before and 4 hours after administration of drug 2:

• Antacids.

• Cimetidine.

• Carafate.

• Cholestyramine resin.

• Alcohol and alcohol-containing substances.

• Benzodiazepines (diazepam, triazolam).

Patients with the following are excluded:

• History of clinically important disease (defined as a disease that, in the opinion of the investigator, may either put the patient at risk because of participation in the study or a disease that may influence the results of the study or the patient's ability to participate in the study) other than HIV infection.

• Malignancy other than Kaposi's sarcoma or limited cutaneous basal cell carcinoma.

Prior Medication:

Excluded within 4 weeks prior to administration of study drug 2:

• Antiretroviral (other than zidovudine (AZT)), immunosuppressive, or cytotoxic drugs.

• Glucocorticoids and steroid hormones (including oral contraceptives).

• Dicumarol, warfarin, and other anticoagulant medications.

• Nitroglycerin.

• Digitoxin.

• Valproic acid.

• Tolbutamide.

• Doxycycline.

• Chloramphenicol Isoniazid.

• Antiepileptics (Phenobarbital and other barbiturates).

• Sulfonamides.