An International Study of the Safety and Tolerability of Corlux for Psychotic Symptoms in Psychotic Major Depression
Status:
Completed
Trial end date:
2006-07-01
Target enrollment:
Participant gender:
Summary
Corlux (mifepristone) is a new medication that modulates the body's use of a hormone called
cortisol. Under normal conditions, cortisol and other hormones are created by the body in
response to physical and emotional stress, triggering a healthy stress response. People who
suffer from psychotic major depression may have unusually high levels of cortisol circulating
within them or abnormal patterns of cortisol levels, overloading the stress response
mechanism and causing symptoms of psychosis such as delusional thoughts or hallucinations. If
Corlux can keep the body's cortisol receptors from being overloaded, the stress response
system may return to normal function, which may result in improvement of symptoms. The
purpose of this 56 day study is to learn the safety and effectiveness of Corlux in patients
who have been diagnosed with psychotic major depression (PMD).