An Exploratory Study of Naltrexone Plus Aripiprazole for Alcohol Dependence
Status:
Completed
Trial end date:
2011-05-01
Target enrollment:
Participant gender:
Summary
The principal aim of this exploratory study is to examine whether the addition of
aripiprazole to naltrexone will enhance efficacy over naltrexone alone in a 16-week
randomized, placebo-controlled clinical trial, in which all subjects will be provided medical
management as delivered in the COMBINE Study (Anton et al, 2006). To test whether medication
treatment will reduce drinking compared to placebo treatment alone in the context of medical
management and whether naltrexone plus aripiprazole will reduce drinking compared to
naltrexone treatment alone in the context of medical management.
Phase:
Phase 2
Details
Lead Sponsor:
Medical University of South Carolina
Collaborator:
National Institute on Alcohol Abuse and Alcoholism (NIAAA)