Plaque psoriasis may be an ideal model disease to explore potential therapeutic effects of
immunosuppressive agents, given the easy accessibility of inflammatory lesions. In this
study, the applicability of a systems dermatology approach is investigated in order to better
assess the efficacy of psoriasis treatments at an early clinical stage. Up to this point, the
clinical manifestation and regression of psoriasis is not yet sufficiently characterized with
a multimodal state-of-the-art evaluation tool. The in-house developed 'DermaToolbox' enables
the determination and subsequent integration of different diseaserelated biomarkers,
including clinical, biophysical, molecular, cellular, and imaging markers as well as patient
reported outcomes