An Experimental Study to Compare Treatment Response and Toxicities of Concurrent Chemoradiation With Weekly Cisplatin and Three Weekly Cisplatin in Locally Advanced Head and Neck Cancer.

• Status: Completed
• Trial end date: 2018-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to compare treatment responses and toxicities of concurrent chemo-radiation with weekly and three weekly Cisplatin in locally advanced Head & Neck Cancer. Half of the participants received Cisplatin (40 mg/m2) weekly with radiotherapy, while the other half received Cisplatin (100 mg/m2) thrice weekly with radiotherapy. Radiotherapy continued five days per week for six and half weeks.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
• Treatments: Cisplatin

Criteria

Inclusion Criteria:

• Biopsy proved, previously untreated, Squamous cell carcinoma of head & neck

• Stages III to IVB

Exclusion Criteria:

• Patients with history of prior chemotherapy or radiotherapy to the head and neck region.

• Initial surgery (excluding diagnostic biopsy) of the primary site.

• Patients with synchronous primaries.

• Those who are not willing to be included in the study.

• Pregnant or lactating woman.

• Serious medical illness

• Prisoners.