An Assessment of an Attenuated Live Listeria Vaccine in CIN 2+
Status:
Terminated
Trial end date:
2016-04-01
Target enrollment:
Participant gender:
Summary
Cervical cancer is associated with Human Papilloma Virus. About 57% of cervical cancer is the
result of infection by Human Papilloma Virus strain 16 (HPV-16). HPV is a very common virus
that can affect the cells of the cervix. E7 is a substance that is made by the HPV virus
which causes cervical cancer. The purpose of the study is to test the safety, tolerability
(how the drug makes you feel), immunology (effects on the immune system) and efficacy
(disease curing effects) of a vaccine called Lovaxin C against E7. The vaccine is designed to
cause the immune system to react against the E7 substance in a manner that is intended to
reverse the changes to the cervix and prevent cervical cancer from occurring.