An Adaptive Design Trial Of GW274150 In The Treatment Of Acute Migraine
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Nitric oxide (NO) is likely to be involved in the development of migraine headache. Nitric
oxide synthase (NOS) is an important chemical involved in the production of NO. Reduction of
NOS, and therefore NO, may be an effective technique for the treatment of migraine headache.
GW274150 is a highly selective inhibitor of NOS and offers the potential of anti-inflammatory
activity in migraine through a novel mechanism of action. The intent of this study is to
investigate the safety and efficacy of GW274150 for the acute treatment of migraine headache.