An Adaptive Algorithm-Based Approach to Treatment for Adolescent Depression
Status:
Recruiting
Trial end date:
2022-10-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate the effectiveness of two adaptive treatment
strategies (ATSs) for adolescent depression. The ATSs include delivery of an evidence-based
psychotherapy (interpersonal psychotherapy for depressed adolescents, IPT-A), systematic
symptom monitoring, and an empirically-derived algorithm that specifies whether, when, and
how to augment IPT-A. Two hundred depressed adolescents (age 12-18) will be recruited to
participate in a 16-week sequential multiple assignment randomized trial conducted in
outpatient community mental health clinics. Adolescents will be randomized to the IPT-A ATS
condition or the community clinic's usual care (UC). Adolescents in the IPT-A ATS condition
who are insufficient responders will be randomized a second time to the addition of a
selective serotonin reuptake inhibitor (SSRI) or more intensive IPT-A (delivered twice per
week). Research assessments will be administered at baseline and at weeks 4, 8, 12, 16, and
36.
Phase:
Phase 2
Details
Lead Sponsor:
University of Minnesota University of Minnesota - Clinical and Translational Science Institute