Amyloid Accumulation After Mild Traumatic Brain Injury
Status:
Unknown status
Trial end date:
2013-10-01
Target enrollment:
Participant gender:
Summary
There will be 200 participants, who aged 30 years or older with TBI in 1,5,10,15 years ago
and GCS=13-15 will be recruited. Another group of 200 participants with the same age and
gender and without TBI will be recruited as the controls. All of them will undergo AD8
questionnaire for dementia screening and APOE4 genotyping. Further CASI and CDR will be
tested for the confirmation of dementia diagnosis for the individuals with AD8 scaore >/=2.
10 TBI with dementia, 20 TBI without dementia and 10 controls will be selected randomly for
AV45 amylid PET study.
There will also be 10 participants without traumatic brain injury and interested in this
study, aged 55 years or older better.