This is an NIH Pilot Clinical Trial Grant designed to provide data to permit the rationale
design of a subsequent efficacy study. The purpose of this project is to determine the
potential benefit of amphetamine combined with physical therapy in enhancing motor recovery
in patients admitted for inpatient rehabilitation between 10 and 30 days after hemispheric
ischemic stroke. The study hypotheses are: 1, The addition of treatment with d-amphetamine
will result in at least a 12.6 point improvement in the Fugl-Meyer motor score 3 months after
stroke. 2, There will be no clinically significant increase in the frequency of serious
adverse events associated with treatment with d-amphetamine which would preclude further
testing.