Amoxicillin/Metronidazole Based Quadruple Therapy for Helicobacter Pylori Eradication

• Status: Completed
• Trial end date: 2015-01-01
• Target enrollment: 0
• Participant gender: All

Summary

No trial has examined the the efficacy of amoxicillin and metronidazole based quadruple therapy for Helicobacter pylori treatment. The study aims to compare the effectiveness and safety of 14-day amoxicillin-/metronidazole-based quadruple regiment and classical quadruple regiment for Helicobacter pylori eradication.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shanghai Jiao Tong University School of Medicine
• Treatments: Amoxicillin; Anti-Bacterial Agents; Antibiotics, Antitubercular; Bismuth; Citric Acid; Clarithromycin; Dexlansoprazole; Lansoprazole; Metronidazole; Potassium Citrate; Proton Pump Inhibitors

Criteria

Inclusion Criteria:

• Participants with non-investigated/functional dyspepsia or scarred peptic ulcer with indication of H pylori eradication treatment

• Ability and willingness to participate in the study and to sign and give informed consent

• confirmed H pylori infection by at least one of the following methods: C13-urea breath test, histology, rapid urease test or bacterial culture.

Exclusion Criteria:

• patients with peptic ulcer

• previous H. pylori eradication therapy

• Age below 18 years

• major systemic diseases

• previous gastric surgery

• pregnancy or breastfeeding

• allergy to any of the study drugs

• receipt of anti-secretory therapy, antibiotics or bismuth salts 4 weeks prior to inclusion