Amlodipine on Blood Flow of Preovulatory Follicle in Polycystic Ovarian Patients

• Status: Completed
• Trial end date: 2015-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

On the basis of the current study, amlodipine seems to be a promising drug on improving uterine, ovarian blood flow, size of pre-ovulatory follicle, midluteal progesterone level and pregnancy outcome in patients with pco.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ahmed Fathy Ali Mohamed Ghanem
• Treatments: Amlodipine; Citric Acid; Clomiphene; Enclomiphene; Zuclomiphene

Criteria

Inclusion Criteria:

• Demographic features including females in age of ≥20 & ≤35, and BMI of ≤39.

• Infertility secondary to polycystic ovary , The choice of polycystic ovary patients will be according to the Rotterdam consensus workshop (Rotterdam, 2004), and the diagnosis of polycystic ovary by ultrasonography will be made according to Adams et al. criteria which are the most often cited (Adams et al., 1985).The Rotterdam criteria as follows:

• Oligo- or anovulation.

• Clinical and/or biochemical signs of hyper androgynism

• The presence of polycystic ovaries on ultrasound scan. Ultrasound findings of enlarged ovaries with multiple small cysts (10-12 or more of 2-9 mm in diameter) scattered around the periphery and highly echogenic stroma

Exclusion Criteria:

• Including other causes of infertility diagnosed during infertility work up.

• Patients refused to participate or to continue study.

• Also, hepatic, cardiac, and hypotensive patients will be excluded from the study.