Patients with type 1 diabetes mellitus (T1DM) commonly experience hypoglycemia and develop
impaired awareness of hypoglycemia. Many patients using continuous glucose monitoring (CGM)
system to mitigate these complications, but continue to spend a significant amount of time in
hypoglycemia. The long-term goal is to develop novel and readily available therapeutic
approaches to improve hypoglycemia course and awareness in T1DM patients. The objective of
this study is to determine whether amitriptyline will improve hypoglycemia course and the
ability to recognize hypoglycemic events in T1DM patients who are using CGM.
Phase:
Phase 2
Details
Lead Sponsor:
University of Utah Yu Kuei (Alex) Lin, MD
Treatments:
Amitriptyline Amitriptyline, perphenazine drug combination