This study will investigate the effects of a contingency-based musical walking intervention
program called Ambulosono on neural mechanisms in the brain. The investigators will
investigate the long-term impact of Ambulosono on brain plasticity with functional MRI
technique. Participants will undergo 3 months of Ambulosono training and their pre-training
and post-training fMRI brain scans will be compared to understand the neural networks and
brain mechanisms following this intervention. The investigators hypothesized that Ambulosono
may induce functional compensatory reorganization of neural networks in the brain. This
project will allow us to address the important potential confound of placebo influence and to
aid in optimizing this intervention program. Additionally, the investigators are hoping to
investigate the synergistic effects of rasagiline and exercise; the investigators' hypothesis
is that there will be a positive synergistic effect, and that exercise will augment the
effectiveness of rasagiline in treating Parkinson's symptoms.
Phase:
N/A
Details
Lead Sponsor:
University of British Columbia
Collaborators:
Teva Branded Pharmaceutical Products R&D, Inc. Teva Pharmaceutical Industries