Amantadine for Improving Neurologic Symptoms in Ataxia-Telangiectasia
Status:
Completed
Trial end date:
2009-11-01
Target enrollment:
Participant gender:
Summary
Ataxia-Telangiectasia A-T is a neurodegenerative disorder of the cerebellum, manifesting with
ataxia, as well as extrapyramidal features. Treatment of A-T is discouraging, since no
treatment seems to change the course of disease, but improvement can be achieved by
symptomatic treatment of the bothersome movement disorder . While various dopaminergic agents
are occasionally used, reports of benefit are rather sparse and anecdotal. Amantadine, a well
known drug used in influenza as well as movement disorder of Parkinson, has been proved to
improve various other types of movement disorder as ataxia, chorea, dystonia, akinesia and
attention span. The purpose of this study is to investigate weather amantadine sulphate
improves ataxia and the movement disorder (bradykinesia, parkinsonism, dystonia, chorea), as
well as the general well being in patients with A-T.